26803777
2016
1
24
2016
1
25
1573-2517
194
2016
Jan
13
Journal of affective disorders
J Affect Disord
The natural history of depression and trajectories of symptoms long term after stroke: The prospective south London stroke register.
65-71
S0165-0327(15)31162-9
10.1016/j.jad.2016.01.030
The natural history of depression in stroke patients is complex and the mechanism of change in symptoms over time is not fully understood. We hypothesise that there are different trajectories of symptoms after stroke.
The primary analysis comprised 761 patients who completed 5 years follow up, obtained from the prospective South London Stroke Register (1998-2013). The Hospital Anxiety and Depression scale (HADs) was used to screen patients for depression symptoms at 3 months after stroke, then annually. Trajectories of depression symptoms were detected using group based trajectory modelling (GBTM).
Four patterns of symptoms (Groups I-IV) were identified: 6.31% of patients had severe symptoms, improved slightly in early years then worsen (predicted mean HADs score, 15.74 (se=1.06)); 28.65% had moderate symptoms, a tendency to get worse over time, predicted mean score 7.36 (se=0.35); 49.54% had mild symptoms and a tendency of getting worse, predicted mean 3.89 (se=0.30), and 15.51% of the cohort, had no symptoms and remained so over time. The lowest rate of Selective serotonin reuptake inhibitors (SSRI) use, over 5 years after stroke was 1.1% for group (I) and highest was 35% for group (IV). Sensitivity analyses were used to assess the robustness of the findings using several inclusion criteria and findings agreed with the primary results.
There is loss to follow up of around 20%.
The study identified 4 trajectories of depression symptoms, providing useful information for the long term management of stroke patients and for the implementation of cost effective personalized interventions.
Copyright © 2016 Elsevier B.V. All rights reserved.
Ayis
Salma A
SA
Division of Health and Social Care Research King's College London, London, UK. Electronic address: salma.ayis@kcl.ac.uk.
Ayerbe
Luis
L
Division of Health and Social Care Research King's College London, London, UK; Blizard Institute. Centre for Primary Care and Public Health, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, UK.
Crichton
Siobhan L
SL
Division of Health and Social Care Research King's College London, London, UK.
Rudd
Anthony G
AG
Division of Health and Social Care Research King's College London, London, UK; Stroke Unit, Guy's and St. Thomas' NS Foundation Trust, St. Thomas' Hospital, London, UK.
Wolfe
Charles D A
CD
Division of Health and Social Care Research King's College London, London, UK; National Institute for Health Research (NIHR) Biomedical Research Centre, Guy's and St Thomas' NHS Foundation Trust, London, UK; National Institute for Health Research (NIHR) Collaboration for Leadership in Applied Health Research and Care (CLAHRC) South London at King's College Hospital NHS Foundation Trust, UK.
ENG
JOURNAL ARTICLE
2016
1
13
J Affect Disord
7906073
0165-0327
Depression symptoms
Group based trajectory modelling (GBTM)
Natural history of depression
Stroke
2015
10
25
2015
12
15
2016
1
12
2016
1
25
6
0
2016
1
25
6
0
2016
1
25
6
0
aheadofprint
S0165-0327(15)31162-9
10.1016/j.jad.2016.01.030
26803777
26803758
2016
1
24
2016
1
25
1590-3478
2016
Jan
23
Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology
Neurol. Sci.
Asterixis in the leg induced by anterior cerebral artery infarction.
Asterixis commonly occurs in a patient with metabolic encephalopathy, whereas focal brain lesions such as thalamus, cerebellum, or frontal area also cause focal or unilateral asterixis in the arms. We report a novel case of asterixis in the leg after unilateral anterior cerebral artery territory infarction. A 76-year-old man was admitted with sudden-onset mild right leg weakness and postural instability due to knee buckling. He was diagnosed with ischemic stroke in the left prefrontal area and cingulated gyrus by brain magnetic imaging. Needle electromyography of the right vastus lateralis muscle while standing showed intermittent periods of EMG silence, consistent with asterixis. There were no abnormal involuntary movements in the upper extremities. This case suggests that gait disturbance or postural instability after structural lesions in the prefrontal area may be directly related to asterixis in the leg, not in the arm associated with postural failure.
Sunwoo
Mun Kyung
MK
Department of Neurology, Bundang Jesaeng General Hospital, Seongnam, South Korea.
Jang
Hyun-Soon
HS
Department of Neurology, Bundang Jesaeng General Hospital, Seongnam, South Korea.
Roh
Sook Young
SY
Department of Neurology, Bundang Jesaeng General Hospital, Seongnam, South Korea.
Yoo
Hyun Jung
HJ
Department of Neurology, Bundang Jesaeng General Hospital, Seongnam, South Korea.
Jeong
Eun Hye
EH
Department of Neurology, Bundang Jesaeng General Hospital, Seongnam, South Korea.
Kim
Byung-Su
BS
Department of Neurology, Bundang Jesaeng General Hospital, Seongnam, South Korea.
Choe
Yeo Reum
YR
Department of Rehabilitation, Bundang Jesaeng General Hospital, 20, Seohyun-ro 180, Bundang gu, Seongnam, Kyunggo-do, 463-774, South Korea.
Lee
Ko-Eun
KE
Department of Rehabilitation, Bundang Jesaeng General Hospital, 20, Seohyun-ro 180, Bundang gu, Seongnam, Kyunggo-do, 463-774, South Korea. rhsrhs2u@gmail.com.
ENG
JOURNAL ARTICLE
2016
1
23
Neurol Sci
100959175
1590-1874
Anterior cerebral artery territory infarction
Asterixis
Movement disorder
Prefrontal
2015
9
23
2016
1
13
2016
1
23
2016
1
25
6
0
2016
1
25
6
0
2016
1
25
6
0
aheadofprint
10.1007/s10072-016-2486-0
10.1007/s10072-016-2486-0
26803758
26803725
2016
1
24
2016
1
25
1872-6968
142
2016
Jan
12
Clinical neurology and neurosurgery
Clin Neurol Neurosurg
Lack of association between TOR1A and THAP1 mutations and sporadic adult-onset primary focal dystonia in a Chinese population.
26-30
S0303-8467(16)30016-6
10.1016/j.clineuro.2016.01.018
TOR1A (torsin family 1, member A) and THAP1 (THAP domain containing, apoptosis associated protein 1) are two candidate genes that have been reported to be linked to adult-onset primary dystonia. However, the overall results have been inconsistent, likely because primary dystonia may have subtype-specific genetic risk factors. The aim of our study was to assess the association of TOR1A and THAP1 with adult-onset primary focal dystonia (AOPFD), the most common subtype of primary dystonia.
A total of 248 subjects, comprising 117 AOPFD patients and 131 healthy controls, were included in our study. All coding exons of TOR1A and THAP1 were initially analyzed in the 117 patients. Subsequently, we investigated the association of two common TOR1A variants (rs2296793, rs1801968) with AOPFD in a Chinese population (117 patients versus 131 controls) and performed a pooled analysis by combining our data with previously published data.
No mutation of TOR1A and THAP1 was found other than two TOR1A variants (rs2296793, rs1801968), which have been previously reported in AOPFD patients. There were no statistically significant differences in the minor allele frequency (MAF) and genotype frequency between AOPFD and controls in our Chinese population (P>0.05). This result was confirmed by pooled analysis of multi-ethnic groups.
Our study suggested that there might not be an association between TOR1A or THAP1 and patients with AOPFD.
Copyright © 2016 Elsevier B.V. All rights reserved.
Wang
Lei
L
Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025 China; Laboratory of Neurodegenerative Diseases & Key Laboratory of Stem Cell Biology, Institute of Health Science, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Duan
Chenchi
C
Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025 China.
Gao
Yuan
Y
Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025 China; Laboratory of Neurodegenerative Diseases & Key Laboratory of Stem Cell Biology, Institute of Health Science, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Xu
Wei
W
Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025 China; Laboratory of Neurodegenerative Diseases & Key Laboratory of Stem Cell Biology, Institute of Health Science, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Ding
Jianqing
J
Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025 China; Laboratory of Neurodegenerative Diseases & Key Laboratory of Stem Cell Biology, Institute of Health Science, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Liu
Victoria T
VT
Human Motor Control Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, China.
Wu
Yiwen
Y
Department of Neurology & Institute of Neurology, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025 China; Laboratory of Neurodegenerative Diseases & Key Laboratory of Stem Cell Biology, Institute of Health Science, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS) & Shanghai Jiao Tong University School of Medicine, Shanghai, China. Electronic address: consentir@126.com.
ENG
JOURNAL ARTICLE
2016
1
12
Clin Neurol Neurosurg
7502039
0303-8467
Adult-onset primary dystonia
Chinese population
Single nucleotide polymorphism
THAP1
TOR1A
2015
5
25
2016
1
5
2016
1
9
2016
1
25
6
0
2016
1
25
6
0
2016
1
25
6
0
aheadofprint
S0303-8467(16)30016-6
10.1016/j.clineuro.2016.01.018
26803725
26803722
2016
1
24
2016
1
25
1532-8511
2016
Jan
20
Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association
J Stroke Cerebrovasc Dis
Drops in Barometric Pressure Are Associated with Deep Intracerebral Hemorrhage.
S1052-3057(15)00652-7
10.1016/j.jstrokecerebrovasdis.2015.11.027
The objective of this study is to assess the effects of changes in barometric pressure and outdoor temperature on the incidence of different subtypes of intracerebral hemorrhage (ICH).
Consecutive patients with primary supratentorial ICH were included. All patients resided in the same geographic area. We compared patients with subcortical ICH to those with cortical ICH. Meteorological data were continuously accrued. High-risk ICH days were defined as those on which 1 or more patients with ICH were admitted and compared to non-high-risk days. We analyzed the relationship between spontaneous ICH location and averaged daily atmospheric pressures and temperatures.
We included 206 patients (147 with deep ICH and 59 with lobar ICH). Patients with deep ICH were younger (P < .001), more often had histories of diabetes, smoking and previous lacunar strokes, and were more often male (P < .01 for all). Drops in mean air pressure 2 days prior to the ictus were associated with deep but not lobar ICH (P = .006). Deep ICH clustered during February months in parallel with larger changes in barometric pressures (P < .001).
Drops in daily atmospheric pressures were associated with deep but not cortical ICH, suggesting a link to hypertensive etiology. Changes in barometric pressures were also associated with higher monthly frequencies of ICH.
Copyright © 2015 National Stroke Association. Published by Elsevier Inc. All rights reserved.
Honig
Asaf
A
Department of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Eliahou
Ruth
R
Department of Radiology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Pikkel
Yoav Y
YY
Department of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel.
Leker
Ronen R
RR
Department of Neurology, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. Electronic address: leker@hadassah.org.il.
ENG
JOURNAL ARTICLE
2016
1
20
J Stroke Cerebrovasc Dis
9111633
1052-3057
Barometric pressure
acute stroke
hypertension
intracerebral hemorrhage
rapid improvement
stroke outcomes
stroke treatment
thrombolysis
2015
8
14
2015
10
19
2015
11
22
2016
1
25
6
0
2016
1
25
6
0
2016
1
25
6
0
aheadofprint
S1052-3057(15)00652-7
10.1016/j.jstrokecerebrovasdis.2015.11.027
26803722